Sean (Kerr Smith) is driving cross-country to deliver a vintage Mercedes and attend his sister's wedding when he picks up a hitchhiker, Nick (Brendan Fehr), who just happens to be a vampire hunter, tracking down a group of youthful vampires that feed on unwary travelers. As the plot thickens, they run into Megan, (Isabella Miko) who has been left for dead by the vampires. As they use her as a lure for the vampires, Sean becomes attracted to her. Further complications ensue when Sean is infected with the vampire virus. He, Megan and Nick must race against time to kill the vampire leader (Jonathon Schaech) to stop Sean from becoming one of the undead.