As Scary Movie 2 begins, a young girl, Megan Voorhees (Natasha Lyonne), is possessed by a demon and two priests, Father McFeely (James Woods) and Father Harris (Andy Richter), must drive it out, but they fail miserably after bad things happen, including tongues being stuck out by Megan and Father McFeely, and all three people vomiting green pea soup on each other. A year later, the survivors from the first Scary Movie, heroine Cindy Campbell (Anna Faris), gay jock Ray Maker (Shawn Wayans), drug dealer Shorty Meeks (Marlon Wayans), and Shorty's still chatty sister, Brenda (Regina Hall), are at college, trying to forget the incidents that occurred last Halloween. Cindy is falling in love with Buddy (Christopher Kennedy Masterson), a guy who likes to give people wedgies and Ray is still confused about his sexuality. As a school project, their professor, Professor Oldman (Tim Curry), and his paralyzed assistant, Dwight (David Cross), have decided to do a research study at Hell House, the house where the bad exorcism took place, and disguise it as a sleep disorder study. But chaos starts when Cindy arrives and meets Hanson (Chris Elliot), the house's crazy caretaker who has a deformed hand that grosses people out when they see it. But the house has its hidden secrets and Cindy, Buddy, Ray, Shorty, Brenda, the Professor, Dwight, Theo (Tori Spelling), and Jamie Lee Curtisto (Kathleen Robertson) must find those secrets out, even if they are disgusting.